FulGenome from Fulgent Genetics

A female scientist reviewing DNA sequencing data on a computer screen in a laboratory.

Full Insight When Every Detail Matters

FulGenome is a next-generation whole genome sequencing (WGS) solution designed to provide comprehensive genomic insights through a single, streamlined report. Leveraging advanced sequencing technology and our proprietary bioinformatics pipeline, FulGenome delivers enhanced variant detection, including single nucleotide variants (SNVs), copy number variants (CNVs), genome-wide del/dups, mitochondrial genome alterations, and repeat expansions.

The optional addition of RNA analysis (RISE) enables deeper characterization of functional impact, providing a powerful tool for clinicians.

Features

3-5 week turnaround time
Multi-variant analysis
Single, integrated report

Variant Detection

Single nucleotide variants (SNVs)
Copy number variants (CNVs)
Genome-wide del/dups
Mitochondrial genome alterations
Repeat expansions

Who is FulGenome for?

Rare Disease Diagnostics

Offers a high diagnostic yield in patients with complex, undiagnosed conditions.

Pediatric Genetics

Early diagnosis of genetic disorders in newborns and children can be critical for timely medical interventions.

Broad Clinical Evaluation

Supports clinical decision-making across a range of specialties by offering a comprehensive view of the genome.

Pediatrician in a medical checkup with mom and young boy.

What Sets Us Apart

PCR-Free NGS Advantage

Provides more uniform coverage and reduces amplification bias from traditional PCR-based library preparation, leading to higher accuracy in variant calling.

Exceptional Resolution

Detects CNVs with >2 exon resolution and genome-wide del/dups, surpassing traditional exome sequencing.

Enhanced Diagnostic Yield

Whole genome sequencing has been shown to improve positive diagnostic rates compared to exome by capturing non-coding variants beyond +/- 20 intronic junctions, mitochondrial genome variants, and structural changes often missed in exome-based approaches.

Integrated RNA Analysis

Provides functional insights into genetic variants, enabling deeper characterization of pathogenicity. Detects aberrant gene expression, mono-allelic gene expression, and aberrant splicing of expressed target genes.

Streamlined Reporting

Unlike traditional testing requiring multiple separate analyses, FulGenome consolidates key insights into a single, comprehensive report.

Flexible Options

Add on ACMG secondary findings, duo/trio analysis*, and/or complimentary PGx analysis as needed.

*Analysis limited to DNA analysis of SNVs and CNVs.

SUPPLEMENTAL TESTING

Discover RNA-Integrated Sequence Evaluation (RISE)

RISE integrates whole exome or genome sequencing with RNA sequencing to enhance diagnostic accuracy for complex or undiagnosed cases. By evaluating the RNA-level effects of genetic variants, including those in coding, splice site, and regulatory regions, RISE maximizes clinical insights.

Learn More

Benefits of RISE

Evidence-Based Yields

Up to 36% diagnostic yield in previously undiagnosed WES/WGS cases

Clearer Insights

Refines DNA variant classification to increase diagnostics rate

Richer Analysis

Detects gene expression impact of coding and noncoding variants

TEST DETAILS

Whole genome sequencing (WGS) using next-generation sequencing (NGS) technology to deliver enhanced variant detection, including single nucleotide variants (SNVs), copy number variants (CNVs), genome-wide del/dups, mitochondrial genome alterations, and repeat expansions.