Beyond Expectations: Prenatal Screening for the Future
KNOVA Prenatal Cell-Free DNA Screening is an advanced genetic test that can be performed as early as 10 weeks into a pregnancy to screen for more genetic conditions than any other prenatal test. With a simple maternal blood draw, KNOVA can help identify pregnancies at risk for certain severe, early-onset disorders.
We leverage cutting-edge technology to provide expectant parents with thorough and accurate information rooted in evidence-based practices, facilitating a pathway to proactive prenatal care and peace of mind.
As a screening test, KNOVA identifies pregnancies at high risk for certain conditions. KNOVA is not diagnostic - if a high-risk pregnancy is identified, further diagnostic testing (during pregnancy or postnatally) is required to know whether the baby is affected. Decisions about a pregnancy should not be made using the KNOVA test alone. Rather, this test should be used to help identify risk at an early stage.
Unparalleled Insights
Coverage beyond the standard chromosomal conditions means more knowledge for you and your patients.
Comprehensive Coverage
| Autosomal Trisomies | 6 types Trisomy 13*, Trisomy 15, Trisomy 16, Trisomy 18*, Trisomy 21*, Trisomy 22 |
| Sex Chromosome Aneuploidies | 4 types 45,X; 47,XXX; 47,XXY; 47,XYY |
| Chromosomal Microdeletions | 12 microdeletions 1p36 del, 2q33 del, 4p16 del, 5p15 del, 8q23q24 del, 9p del, 11q23q25 del, 15q11.2-q13 del, 17p11.2 del, 18p del, 18q22q23 del, 22q11.2 del |
| Single Genes | 56 genes, associated with 30+ monogenic conditions ASXL1, BRAF, CBL, CD96, CDKL5, CHD7, COL10A1, COL11A1, COL1A1, COL1A2, COL2A1, EBP, EFNB1, ERF, FGFR1, FGFR2, FGFR3, FLNB, FREM1, GLI3, HDAC8, HNRNPK, HRAS, KAT6B, KMT2D, KRAS, LMNA, MAP2K1, MAP2K2, MECP2, NIPBL, NRAS, NSD1, NSDHL, PTPN11, RAD21, RAF1, RIT1, RUNX2, SHOC2, SKI, SLC25A24, SMC1A, SMC3, SNRPB, SOS1, SOS2, SOX9, SPECC1L, STAT3, TCF12, TRAF7, TSC1, TSC2, TWIST1, ZIC1 |
*Twin pregnancies and egg donor-derived singleton pregnancies can only receive testing for these three trisomies (13, 18, and 21) with our CORE Aneuploidy Panel. Our FULL KNOVA panel is appropriate for singleton pregnancies only; testing cannot be performed for cases with a history of egg donor, fetal demise, vanishing twin, or reduction.
Robust Clinical Validation*
Concurrent Analysis
Evaluates for pregnancies at high risk for fetal pathogenic variants on both the chromosomal and single-gene levels
Gold Standard Performance
98.5% sensitivity and 99.3% specificity relative to standard diagnostics (based on a study of 1000+ participants at increased risk for fetal genetic conditions)
Higher Detection Rate
Inclusion of targeted monogenic conditions led to a 60.7% increase in detection rate
How Does the Testing Process Work?
Collect Sample
Email us to request a kit.
Complete TRF
Download and fill out the
test requisition form.
test requisition form.
Ship
Return specimen and completed TRF to our lab as soon as possible.
Receive Report
Results will be available in 7-10 days (from lab receipt of sample).
Eligibility
- Patients eligible for the comprehensive KNOVA Prenatal Cell-Free DNA Screening include those with singleton pregnancies of at least 10 weeks gestation.
- Twins and IVF pregnancies using an egg donor are only eligible for autosomal aneuploidy testing.
- Higher order multiples (triplets and higher) are not eligible for this test.
Contact Us
We'd love to work with you. Please fill out this form and our team will be in touch.